The Effectiveness of Aescin Diethylamine Salicylate in Alleviating Peri-orbital oedema ollowing Septorhinoplasty: Follow-up Study in Basrah, Iraq

Abstract

Background: Periorbital oedema following septorhinoplasty is one of the major complications. Various measures have been advocated to alleviate this issue, including the use of a variety of chemical and/or physical materials, such as Aescin. Aim: This study aims to evaluate the role of Aescin in reducing peri-orbital oedema following septorhinoplasty. Methods: Fifty-four patients underwent primary septorhinoplasty at both Syaab and Saddar Teaching Hospitals in Basrah, Iraq, from September 2023 to September 2024. This randomized prospective interventional study collected data from patients using a designed form during the initial interview. The study population was divided into two groups randomly, group A received Aescin in the form of Aescin Diethylamine Salicylate (Reparil 40 mg oral tablet once daily for 10 days), while Group B did not receive Aescin; each group consisted of 27 patients. Patients in both groups were followed regularly on the 1^st, 3^rd, 7th and 1 month post operatively. Results: Of the total 54, 25 patients were males and 29 were females, representing 46.3% and 53.7%, respectively. Female to male ratio was 1.16:1. Patients' ages ranged from 17 to 42 years, with the majority (57%) in the 20-30 years age group. Eighty-seven percent of the studied patients developed peri-orbital oedema post-operatively. In Group A, 85% developed peri-orbital oedema, of which 73% resolved on the first post-operative day with the use of Aescin (Reparil 40 mg tablet). Conclusions: Aescin Diethylamine Salicylate can effectively reduce peri-orbital oedema following septorhinoplasty.