Histopathological spectrum of glomerular diseases over two years in a single center
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Keywords
renal biopsy, histopathology
Abstract
Background: Glomerular diseases are the leading causes of end-stage renal disease globally. Recognizing the glomerular disease pattern in a specific geographical area is crucial for understanding the region's pathobiology as well as the incidence and progression of the disorder. Aim: To determine the overall spectrum of glomerular diseases based on renal biopsy and compare the results with studies from other countries. Methods: This study was conducted at the Nephrology and Renal Transplant Center, Medical City, Baghdad, Iraq from January 2016 to December 2017. The cohort comprised 849 patients aged 3–65 years who were referred to the center for management. Parameters recorded for each patient included name, age, gender, and clinical and laboratory findings. All biopsy specimens were reported by the same pathologist using light and immunofluorescence microscopy. Two pieces from the left kidney were obtained using a gunshot needle (16 or 18 gauge) and placed in 2 mL formalin for histopathologic examination. Results: The mean age was 24.67 ± 15.902 years, with females comprising 53% of the sample. FSGS was the most predominant condition observed in 229 (27.1%) patients, followed by MCD in 215 (25.5%), LN in 189 (22.5%), and MN in 118 (14%) patients. MCD, MN, and IgA glomerulonephritis were more common in males than females, while LN, vasculitis, FSGS, and MPGN were more prevalent in females. Conclusions: The histopathological study of renal biopsies reflects a spectrum of glomerular diseases that show both similarities and differences compared to other countries.
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This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
Ali Jasim Al Saedi , College of Medicine- University of Baghdad- Nephrology and Renal Transplantation Center.
College of Medicine- University of Baghdad- Nephrology and Renal Transplantation Center.
Saad J. Hamza, Consultant physician and nephrologist… Imam Al Sadeq Hospital- Hilla
Consultant physician and nephrologist… Imam Al Sadeq Hospital- Hilla