A Study on Diabetic Foot Disorders in Basrah, Southern Iraq A Study on Diabetic Foot Disorders in Basrah, Southern Iraq
Main Article Content
Keywords
Diabetes Mellitus, Diabetic Foot, Peripheral Neuropathy
Abstract
Background: Diabetic foot disorders (DFD) involve several pathologies affecting the foot of patients suffering with diabetes, such as diabetic peripheral neuropathy, peripheral arterial disease, foot deformity, diabetic foot ulcer and amputation.
Objectives: To measure the prevalence and associated risk factors of DFD in a cohort of patients in Basrah, Iraq.
Methods: This is a cross sectional study that was performed in Basrah Province, Iraq, from 1/1/2019 to 1/8/2019. Patients with diabetes attending Faiha Specialized Diabetes Endocrine and Metabolism Center were screened for DFD. The participants were divided into four groups according to the International Working Group on the Diabetic Foot Classification. Data were analyzed using SPSS version 25 software.
Results: A total of 121 participants (69 females (57%)) were included. Their mean age was 53.7 ± 12.3 years. The mean duration of diabetes was 8 ± 0.6 years and the mean HbA1c was 9.6 ± 2.3%. Those with type 2 diabetes represented 115 (95%) of the total number and 63 (52%) were on insulin-based regimes. Twenty-six (21.5%) patients had callosity. The patients were classified as having no DFD, neuropathy, neuropathy with peripheral artery disease and/or foot deformity and neuropathy with a history of ulcer or amputation at frequencies of 29.8%, 52.1%, 9.1% and 9.1%, respectively. Females and patients with longer diabetes durations were identified as predictors of DFD; the p values were 0.008 and 0.019, respectively. Additionally, no significant association was detected between DFD and the type of diabetes, age and glycemic control.
Conclusions: Approximately two-thirds of the patients with diabetes have DFD in Iraq. DFD were strongly associated with long duration of diabetes and the female gender. It is crucial to conduct a proper and thorough foot examination and screen all patients with diabetes for DFD at their visit to the clinic. Such an examination may prevent the development of active disease, ulcers and, consequently, amputation.
References
2. Mairghani M, Elmusharaf K, Patton D, Burns J, Eltahir O, Jassim G, et al. The prevalence and incidence of diabetic foot ulcers among five countries in the Arab world: a systematic review. J Wound Care. 2017;26(Sup9):S27–S34.
3. Cook JJ, Simonson DC. Epidemiology and health care cost of diabetic foot problems. InThe diabetic foot 2012 (pp. 17-32). Humana Press, Totowa, NJ.4. Al-Kaabi JM, Al Maskari F, Zoubeidi T, Abdulle A, Shah SM, Cragg P, et al. Prevalence and determinants of peripheral neuropathy in patients with type 2 diabetes attending a tertiary care center in the United Arab Emirates. J Diabetes Metab. 2014;5(346):2.
5. Sobhani S, Asayesh H, Sharifi F, Djalalinia S, Baradaran HR, Arzaghi SM, et al. Prevalence of diabetic peripheral neuropathy in Iran: a systematic review and meta-analysis. J Diabetes Metab Disord. 2014;13(1):97.
6. Tabatabaei-Malazy O, Mohajeri-Tehrani M, Madani S, Heshmat R, Larijani B. The prevalence of diabetic peripheral neuropathy and related factors. Iran J Public Health. 2011;40(3):55.
7. Davies M, Brophy S, Williams R, Taylor A. The prevalence, severity, and impact of painful diabetic peripheral neuropathy in type 2 diabetes. Diabetes care. 2006;29(7):1518-22.
8. Gregg EW, Sorlie P, Paulose-Ram R, Gu Q, Eberhardt MS, Wolz M, et al. Prevalence of lower-extremity disease in the US adult population ≥ 40 years of age with and without diabetes: 1999–2000 national health and nutrition examination survey. Diabetes care. 2004;27(7):1591–7.
9. Schaper N. Diabetic foot ulcer classification system for research purposes: a progress report on criteria for including patients in research studies. Diabetes Metab Res Rev. 2004;20(S1):S90–S5.
10. Moxey P, Gogalniceanu P, Hinchliffe R, Loftus I, Jones K, Thompson M, et al. Lower extremity amputations—a review of global variability in incidence. Diabetic Medicine. 2011;28(10):1144–53.
11. Amoah VMK, Anokye R, Acheampong E, Dadson HR, Osei M, Nadutey A. The experiences of people with diabetes-related lower limb amputation at the Komfo Anokye Teaching Hospital (KATH) in Ghana. BMC research notes. 2018;11(1):1–5.
12. Richard J, Schuldiner S. Epidemiology of diabetic foot problems. La Revue de medecine interne. 2008;29:S222–30.
13. Peters EJ, Lavery LA. Effectiveness of the diabetic foot risk classification system of the International Working Group on the Diabetic Foot. Diabetes care. 2001;24(8):1442–7.
14. Apelqvist J, Bakker K, Van Houtum WH, Nabuurs-Franssen MH, Schaper NC. International consensus on the diabetic foot. Schaper NC, Maastricht. 1999.
15. Ibrahim A. IDF Clinical Practice Recommendation on the Diabetic Foot: A guide for healthcare professionals. Diabetes Res Clin Pract. 2017;127:285–7.
16. Maluf KS, Mueller M. Comparison of physical activity and cumulative plantar tissue stress among subjects with and without diabetes mellitus and a history of recurrent plantar ulcers. Clin Biomech. 2003;18(7):567–75.
17. Khawaja N, Abu-Shennar J, Saleh M, Dahbour SS, Khader YS, Ajlouni KM. The prevalence and risk factors of peripheral neuropathy among patients with type 2 diabetes mellitus; the case of Jordan. Diabetol Metab Syndr. 2018;10(1):8.
18. Melmed S, Polonsky KS, Larsen PR, Kronenberg HM. Williams Textbook of Endocrinology E-Book. Canada: Elsevier Health Sciences; 2015 Nov 11. 1833. Available from: https://books.google.iq/books?id=iPIACwAAQBAJ&lpg=PP1&ots=UnDlBKHwMr&dq=Melmed%20S%2C%20Polonsky%20KS%2C%20Larsen%20PR%2C%20Kronenberg%20HM.%20Williams%20Textbook%20of%20Endocrinology%20%5BInternet%5D%20%20Elsevier%20Health%20Sciences%3B%202015.&lr&pg=PP1#v=onepage&q&f=false
19. Basit A, Nawaz A. Preventing diabetes-related amputations in a developing country–steps in the right direction. Diabetes Voice. 2013;58(1):36–9.
20. Alberti KGMM, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO consultation. Diabetic medicine. 1998;15(7):539–53.
21. Saber HJ, Daoud AS. Knowledge and practice about the foot care and the prevalence of the neuropathy among a sample of type 2 diabetic patients in Erbil, Iraq. J Family Med Prim Care. 2018;7(5):967.
22, Schaper N.C., Andros G., Apelqvist J., Bakker K., Lammer J., Lepantalo M, et al. Diagnosis and treatment of peripheral arterial disease in diabetic patients with a foot ulcer. A progress report of the International Working Group on the Diabetic Foot. Diabetes Metab Res Rev. 2012; 28: 218–224. https://doi.org/10.1002/dmrr.2255
23. Daousi C, MacFarlane I, Woodward A, Nurmikko T, Bundred P, Benbow S. Chronic painful peripheral neuropathy in an urban community: a controlled comparison of people with and without diabetes. Diabetic medicine. 2004;21(9):976–82.
24. Dyck PJ, Kratz K, Karnes J, Litchy WJ, Klein R, Pach J, et al. The prevalence by staged severity of various types of diabetic neuropathy, retinopathy, and nephropathy in a population‐based cohort: the Rochester Diabetic Neuropathy Study. Neurology. 1993;43(4):817.
25. Mansour AA. Chronic complications of diabetes in Iraq: experience from southern Iraq. Clin Med Insights Endocrinol Diabetes. 2009;2:CMED. S3657.
26. Abbott RD, Brand FN, Kannel WB. Epidemiology of some peripheral arterial findings in diabetic men and women: experiences from the Framingham Study. Am J Med. 1990;88(4):376–81.
27. Reiber GE, McFarland LV. Epidemiology and health care costs for diabetic foot problems. The Diabetic Foot: Springer; 2006. p. 39–50.
28. Al-Mahroos F, Al-Roomi K. Diabetic neuropathy, foot ulceration, peripheral vascular disease and potential risk factors among patients with diabetes in Bahrain: a nationwide primary care diabetes clinic-based study. Ann Saudi Med. 2007;27(1):25¬31.
29. Börü U.T., Alp R, Sargin H, Koçer A, Sargin M, Lüleci A, et al. Prevalence of peripheral neuropathy in type 2 diabetic patients attending a diabetes center in Turkey. Endocrine journal. 2004;51(6):563–7.
30. Nather A, Bee CS, Huak CY, Chew JL, Lin CB, Neo S, et al. Epidemiology of diabetic foot problems and predictive factors for limb loss. J Diabetes Complications. 2008;22(2):77–82.
31. Young M, Boulton A, MacLeod A, Williams D, Sonksen P. A multicentre study of the prevalence of diabetic peripheral neuropathy in the United Kingdom hospital clinic population. Diabetologia. 1993;36(2):150–4.
32. Partanen J, Niskanen L, Lehtinen J, Mervaala E, Siitonen O, Uusitupa M. Natural history of peripheral neuropathy in patients with non-insulin-dependent diabetes mellitus. NEJM. 1995;333(2):89–94.
33. Tapp R, Zimmet P, Harper C. de C, Balkau B, McCarty DJ, Taylor HR, et al. Diabetes care in an Australian population: frequency of screening examinations for eye and foot complications of diabetes. Diabetes Care. 2004;27:688–93.